Brain cancer vaccine could extend lives of patients by years

This article was taken from: https://www.theguardian.com/society/2018/may/29/brain-cancer-vaccine-could-extend-lives-patients-years-dcvax-tessa-jowell

By Press Association

Trial on people with form of disease that killed Tessa Jowell ‘remarkably promising’
A vaccine could add years to the lives of people with the aggressive form of brain cancer that killed the former Labour cabinet minister Tessa Jowell, trials suggest.

The treatment for people with glioblastoma works by using the immune cells of a patient to target their tumour. Early findings from an 11-year study involving more than 300 people worldwide shows that those given the vaccine were living longer than expected, according to a paper published in the Journal of Translational Medicine.

The Brain Tumour Charity said the preliminary results were “remarkably promising”.

Jowell died this month at the age of 70 after being diagnosed with a glioblastoma multiforme brain tumour last year. The standard treatment is surgery followed by radiotherapy and chemotherapy. Patients who receive this care live for 15-17 months on average.

Of the 331 patients with glioblastoma who took part in the trial, 232 were injected regularly with the DCVax immunotherapy vaccine in addition to standard care; the remaining group were given a placebo.

Every patient whose tumour recurred during the trial was automatically offered the vaccine, meaning 86.4% received the treatment at some point.

The study found patients involved in the trial survived for more than 23 months on average after surgery. Almost a third (30%) of participants were classed as “extended survivors” and lived for an average of 40.5 months after surgery. The longest survivors have lived for more than seven years.

The researchers said: “It appears that patients who survive past a certain threshold time points may continue onwards to unusually long survival times.”

Only seven participants, who were from the UK, US, Canada and Germany, reported any adverse side-effects from the vaccine, the researchers said.

Keyoumars Ashkan, a professor of neurosurgery at King’s College hospital in London and one of the 69 co-authors of the paper, said the interim results of the trial gave “new hope to the patients and clinicians battling with this terrible disease”.

“Although definitive judgment needs to be reserved until the final data is available, the paper published today hints at a major breakthrough in the treatment of patients with glioblastoma,” he said. “Cautious optimism is welcome in an area where for so long the disease and suffering have had the upper hand.”

David Jenkinson, chief scientific officer at the Brain Tumour Charity, said: “These results appear remarkably promising for a community of patients who have been given little hope for decades.

“We need further analysis of the data from this trial and more research in this area to ascertain the role that immunotherapy can play in the battle against brain cancer.”

DCVax has been developed by the American company Northwest Biotherapeutics.